What to Do When Erectile Dysfunction Treatment with Penile Injections Does Not Work

by Alex Shteynshlyuger MD


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-5211.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  Find out our office hours or directions to our office

We offer affordable appointment prices with or without insurance.  Low-cost Viagra (sildenafil) and Cialis (tadalafil) are available to our patients.


Reasons Penile Injections Are Not Effective 

Penile injections with PGE1 (prostaglandin 1) or Trimix (papaverine, phentolamine and prostaglandin E1) are among the most effective treatment options for erectile dysfunction

Injectable medications in the penis often work when a medication such as Cialis stops working and Viagra does not work.

Most Common Reasons Why Penile Injections for ED Stop Working:

Incorrect administration of medications is the most common cause of why penile injections work in the doctor’s office but do not work at home. Penile injections of PGE1 such as Caverject and Trimix for ED should be administered deep inside the penis where the blood flow is (intra-cavernosal)

Often men do not insert the needle deep enough or inject at the wrong angle in the penis; as a result, medication is injected just below the skin and not deep enough to where it needs to be to cause an erection. 

At New York Urology Specialists we make an effort to teach our patients proper injection technique, which is always successful for men if the medication is effective. Please schedule an appointment if you need help.

Medications used for penis injections for the treatment of erectile dysfunction come in two varieties: medications that require or do not require refrigeration. It is important to store medications properly especially when it comes to medications that require refrigeration.  When medications that require refrigeration are not stored properly, they can lose their potency and may not work well. Prostaglandin is particularly volatile and can lose potency quickly.

An incorrect dose of medications for penile injections is used. Medications such as Bimix, Trimix, and QuadMix are custom-prepared medications mixed in compounding pharmacies.  Formula and concentrations of each medication differ among compounding pharmacies. 

As a result, medications are not interchangeable between different pharmacies.  If a new pharmacy is used to order medications, office test injections in the physician office should be performed to make sure that the dose of medications is appropriate.  At New York Urology Specialists, we perform test dosing for all our patients to make sure that the dose is both adequate and not excessive to avoid the risk of a prolonged erection that does not go away.

Common Reasons Why Penile Injections Do Not Work.

There are 2 primary causes of erectile dysfunction: Erectile dysfunction caused by arterial insufficiency and erectile dysfunction caused by corpora-venous occlusive insufficiency.

Penile injections work well for the treatment of erectile dysfunction caused by arterial insufficiency.  A small number of men with severe arterial insufficiency may find that penile injections do not work well for them; for these men, a penile implant is usually the most effective treatment option.

Penile injections with medications such as Trimix often work for some men with mild corpora-venous occlusive insufficiency. For many men suffering from moderate to severe corpora-venous occlusive insufficiency, penile injections usually do not work.  This is one of the reasons why penile Doppler ultrasound is a valuable test in determining the cause of erectile dysfunction and guiding a patient to appropriate treatment.

Men with Peyronie’s disease, especially with severe hourglass appearance, may find that penile injection such as Trimix and PGE1 E work well in the part of the penis toward the tip of the penis but do not cause an adequate erection in the part of the penis involved by the plaque that causes hour-glass appearance.

Men with Low-T (low testosterone) may find that the benefit of penile injections is reduced.  Addressing low T may lead to an improvement in penile injection effectiveness for ED.

Options When Penile Injections are Not Effective

It is important that a patient is taught to inject medication such as prostaglandin E1 and Trimix correctly.  In-office injection of medications to titrate to appropriate dose is an important component of treatment with penile injections and is recommended by the ED treatment guidelines from the American Urological Association.

For patients with low testosterone, testosterone replacement therapy is advisable.  Similarly, patients with other hormonal abnormalities such as low or high thyroid levels or high prolactin levels should have hormonal abnormalities treated.  Weight loss and treatment of high cholesterol and high blood pressure are important components of holistic treatment for erectile dysfunction.

Shockwave therapy for ED is a new treatment option for men with erectile dysfunction.  Shockwave therapy may help some men with vascular erectile dysfunction for whom penile injections do not work well to regain the ability to use penile injections or oral medications for the treatment of ED.

Penile Implant is an Effective Alternative Treatment to Penile Injections

Usually, medications such as Viagra, Cialis and Levitra are tried prior to using penile injections.  Most men progress to using penile injections for ED when an oral medication such as sildenafil (Viagra) does not workVacuum erection devices (VED) are an option but most men give up using VED after a short period of time due to inconvenience.  Typically, vacuum erection devices did not work nearly as well as do penile injections or medication such as Viagra or Cialis.

The most reliable and effective treatment option for men for whom penile injections for the treatment of erectile dysfunction (Bimix, Prostaglandin E1, Trimix, and Quadmix) do not work is a penile implant.  There are 2 types of penile implants: a malleable penile implant and an inflatable penile implant.  Penile implants such as AMS 700 penile prosthesis and Titan Touch Inflatable penis prosthesis have high patient satisfaction.  Penile implants work for men regardless of the cause of ED.  Penile implants can help men with diabetes, high blood pressure and kidney failure among other problems to regain sexual function.

Dr. Alex Shteynshlyuger is among a small number of top urologists in the United States who perform penile implant procedures for men with erectile dysfunction, Peyronie’s disease associated with ED, as well as penile fibrosis caused by priapism.

Where to Get Treatment for ED in NYC?

At New York Urology Specialists, we offer specialized treatment for ED for men. Same-day appointments are available.

Call/text today: 1-646-663-5211 or make an appointment online.  

We treat sexual and erection problems and offer comprehensive STD testing for infections.  We treat penile problems in men, including phimosis, balanitis, penile irritation, and penile redness. We perform a no-scalpel vasectomy, vasectomy reversal, cosmetic circumcision, circumcision revision, penile frenuloplasty. We offer confidential appointments.

Our prices are ED treatment prices are affordable with or without insuranceLow-cost Viagra (sildenafil) and Cialis (tadalafil) are available to our patients.  We offer free insurance verification.

Read Real Stories of Men who Underwent Treatment for ED at New York Urology Specialists.

We offer ED treatment to patients within driving distance to our offices as well as from other states and countries.  Our patients come from New York, New Jersey, Pennsylvania, and Connecticut, and over 30 countries worldwide.

What do Penile Problems Look Like?

You can find pictures of penile problems including before and after treatment images in our image gallery.

What You Need to Know:

Why Choose New York Urology Specialists for Treatment of Erectile Dysfunction?

  • All treatment is performed by a board-certified urologist experienced in treating men with symptoms of ED, premature ejaculation, and other sexual problems using medical therapy, minimally invasive therapies, lasers, and surgery.
  • We are one of the few practices in the region to offer a full range of options for the treatment of sexual, and erection problems in men.
  • We offer diagnostic testing in our office which avoids hospital costs.
  • Extensive Experience: Thousands of men have treated successfully using medical therapy, shockwave therapy for ED, penile injections with Trimix, and penile implant surgery.
  • Confidential and Understanding Care. We understand that most of our patients desire privacy.  We see patients with a variety of urological problems. Your reason for visiting us is entirely confidential.
  • We are one of the few practices in the region to offer a full range of options for the treatment of sexual and erection problems in men.
  • We are conveniently located within 30-60 minute commute to men who are seeking ED treatment in Manhattan, Brooklyn, Queens, Staten Island, Westchester, Long Island, Bronx, and New Jersey.

Scheduling Appointments for ED Treatment at New York Urology Specialists


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-5211.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  Find out our office hours or directions to our office

We offer affordable prices with or without insurance.  Low-cost Viagra (sildenafil) and Cialis (tadalafil) are available to our patients.

We offer weekday, weekend, and evening office hours.

Dr. Alex Shteynshlyuger is a board-certified urologist, who specializes in all aspects of care for sexual problems in men including ED, premature ejaculation, and other sexual concerns.  He has successfully treated hundreds of men with sexual problems including ED and poor libido.


Patients Reviews

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Total Reviews

32

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penis
by on May 12, 2022

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best urology doctor
by on Feb 14, 2021

Dr Alex Shteynshlyuger is the best urology doctor there is. He is attentive, analytical, knowledgeable and skillful. Very confidential with a masterfully professional staff. I would not hesitate in recommending Dr Shteynshlyuger to the world because I am a satisfied patient of his.

solved my problem with ED
by on Jan 29, 2021

Dr. Shteynshlyuger helped to solve my problem with ED

Very Pleased
by on Jan 21, 2021

Very Pleased, I couldn’t have asked for more from Dr. S as well as everyone in the office, The procedure and after was a dream with Dr. S. If you are on the fence, I can tell you, that you will love your experience with Dr. S

THEY TREAT YOU LIKE FAMILY
by on Jan 11, 2021

THEY TAKE GOOD CARE OF YOU AND THEY TREAT YOU LIKE FAMILY AND LOOK OUT FOR YOU

treatment from New York Urology
by on Jan 07, 2021

My problem with ED is gone with my treatment from New York Urology!

What went well

Appointment scheduling Office environment Staff friendliness Wait times Appointment wasn't rushed Listened & answered questions Explained conditions well Trusted the provider's decisions

What could be improved

recommend Dr. Shteynshlyuger
by on Jan 04, 2021

Yes I would recommend Dr. Shteynshlyuger . Effective physician at all levels.

I would highly recommend it to anyone
by on Oct 11, 2020

I saw the reviews about this place and was very hesitant to go but something was telling me to go with them and I don't regret it at all, the doctor did a great job and helped me understand the process plus the staff was amazing I would highly recommend it to anyone! quick story after the procedure I was in soo much pain and called the office on a SUNDAY, the doctor gave me a call back within 15 minutes and prescribed a stronger medication, to me that meant a lot for the doctor to take time from his day on a Sunday to help me.

highly qualified diagnostician
by on Sep 23, 2020

I have been observed by Dr. Alex for many years and I must say that he is a highly qualified diagnostician, and also several times I have received qualified microsurgical assistance and very useful advice. The only reason I put 4 with a plus is a somewhat long wait for the reception.

very friendly staff
by on Apr 12, 2020

excellent doctor and all very friendly staff

Doctor Shteynshlyuger provided me with the care I needed
by on Mar 11, 2020

The staff is very professional. Doctor Shteynshlyuger provided me with the care I needed. The wait, visits, and instructions were brief. I followed his instructions and my issue was resolved. As a patient exercise patience. Follow the instructions and be honest about your condition and what you hope to accomplish be visiting. Thanks again Doctor.

Patient review
by on Jan 24, 2020

Shang Ring circumcision
by on Oct 29, 2019

Overall, it was a good experience. Dr. Shteynshlyuger (Dr. Alex) was very nice, warm and helpful. He performed a Shang Ring circumcision for me and the procedure went well. I'm pleased with the results and there were no complications. If anyone is interested in the shang ring circumcision in the tristate area, then I'd recommend him. The whole procedure is $1850, which includes the initial consultation (provided that ther are no complications) and every follow up visit up to six months.

What went well

Appointment scheduling Office environment Staff friendliness Wait times Appointment wasn't rushed Listened & answered questions Explained conditions well Trusted the provider's decisions

What could be improved

Office very convenient location
by on Aug 13, 2019

Office very convenient location Don’t have to wait for long Staff very friendly Dr shteynshyuer very experienced I had my serviced done in 3 visits now I feel good now Than you Dr. shteynhlyuger

Peronis Disease
by on Aug 04, 2019

Dr Alex was both knowledgeable and concise with his diagnosis and advice which was well received. Dr was her knowledgeable in the subject and provided good advice.

3P Removal
by on Jul 24, 2019

Went to get my penile papule remove. Got done same day, it was fast, great staff, and most importantly, pleased with the result.

Recommendation
by on Jul 18, 2019

Therefore I would like to recommend you to anyone who need your services.

Urology Visit
by on Jul 18, 2019

Staff were all very welcoming. Dr. Alex Shteynshlyuger was very knowledgeable and attentive during my time spent with him.

Outstanding
by on Jul 09, 2019

Went in for a procedure with Dr. Alex and he was very calm and thorough about the the operation and the recovery. From the front desk to his assistants, everyone was very courteous, professional and polite. I highly recommend NY Urologist Specialist. They are outstanding!!!

Friendly , courteous, effiecient and professional
by on Sep 15, 2018

Wyts Wyts recommends New York Urology Specialists via Facebook. September 15, 2018 · Friendly , courteous, effiecient and professional staff members. This office i highly recommend for any and all Urology matters. Dr Alex Shteynshlyuger is very professional and knowledgable easy to communicate with. Thanks Dr Alex

Satisfied Patient
by on Sep 15, 2018

I am very please and satisfied with everything that has been offorded to me by New York Urology Specialist Office.....Dr Alex

Surgical Procedure
by on Sep 01, 2018

Dr Alex and his staff are through professionals in every sense of the word. From initial diagnosis to a period of evaluating and ruling out options, we decided upon a surgical solution, which appears for the most part to have corrected the issue. Thanks to Ana, and the staff, especially Dr. Alex for treating me so well. Best regards, Lee

Review
by on Aug 16, 2018

Outstanding service

A very good doctor
by on Aug 15, 2018

Dr. Alex Shteynshlyugerand is careful, patient, experienced. Uses innovative approaches, that actually yield results. He is indeed a good doctor, in every sense

urology services
by on Apr 11, 2018

I am very satisfied with the treatment I received at new york urology specialist and would recommend them to other patients.they are the very best.

My wife was elated
by on Jan 15, 2018

Well I put it to use last night and man, good job. My wife was elated. u made it much better somehow, so thank u for fixing my penis

Thankful
by on Dec 05, 2017

"Cannot express how thankful I am I found Dr. Shtetnshlyuger. After undergoing surgery to correct a penile torsion I couldn't be happier with the results. A great doctor who is clearly good at what he does. With something as important as your private area, It's nice to be able to rest easy and know you are in good hands.." via HealthGrades.com 12/5/2017

Review
by on Nov 19, 2017

I am writing to thank dr. Alex. He is thorough, professional, knowledgeable, helpful and friendly. I have seen him for ED and prostate issues, and he has explained all my options clearly, and found solutions that have been a great help. thank you! I highly recommend both Dr. Alex and his staff, which I find to be helpful, friendly, knowledgeable and very professional. They are a pleasure to deal with and all have been a great help.

Dr visit
by on Sep 14, 2017

I am very much thankful for meeting Dr Alex .I had a very serious medical problem I visited many doctors but none could not help me it was very difficult for me until I visited Dr Alex after a couple visits my medical problem is no more I feel very great also I felt almost 20 years younger Dr Alex is second to none fantastic doctor. Thanks again Dr Alex from my family.

Excellent doctor
by on Jul 03, 2014

I am feeling better now after visiting clinic New York urology specialists. Excellent staff and appointment on time.

Thank you for excellent care
by on Jan 07, 2013

Dear Dr. Alex: We want to thank you for the excellent care you provided for George during his emergency operation and the follow up treatment. Your quiet, confident manner was reassuring to us during a very scary time for us. We will never forget you. George Sally R. Date: 2013

We love you!
by on Feb 16, 2012

Dr. Alex Shteynshlyuger and Staff – Thank you so much for taking care of my husband Bob. Dr. Alex: I thank God everyday for you. You were an answer to prayer.

ED is Treatable in Nearly Every Man

At New York Urology Specialists, our urologists are specially trained in the evaluation and treatment of erectile dysfunction.  We understand the challenges that ED creates for our patients, their relationships, and their self-esteem.  We help you find a treatment for erectile dysfunction that fits your needs, lifestyle, and your preferences.

Urologists are doctors specializing in the treatment of men with erectile dysfunction. By the virtue of our experience and skill, we are able to offer an effective treatment option for nearly every man who desires an effective treatment for ED.  We offer medical and surgical treatment for erectile dysfunction.

We Treat Some of the Most Complex ED Problems Including:

Schedule an Appointment with Dr. Shteynshlyuger:

Call/text today: 1-646-663-5211 or make an appointment online

Dr. Alex Shteynshlyuger is a fellowship-trained board-certified urologist with expertise in the evaluation and treatment of sexual and erection problems in men using modern effective and proven treatment methods.  We offer inflatable penile implant, shockwave therapy for ED, and treatment for Peyronie’s disease.

He is highly recommended by top primary care physicians in the New York area. If you or someone you know has been experiencing urological symptoms, make an appointment to take advantage of Dr. Shteynshlyuger’s expert advice. Please feel free to contact us with any questions.


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-5211.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  Find out our office hours or directions to our office

We offer affordable appointment prices with or without insurance.  Low-cost Viagra (sildenafil) and Cialis (tadalafil) are available to our patients.

We offer weekday, weekend, and evening office hours.

 

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