Xiaflex vs Verapamil Intra-lesional Plaque Injections for Peyronie’s Disease

by Alex Shteynshlyuger MD


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Xiaflex vs Verapamil Injections: Effectiveness

Peyronie's diseaseThere are no studies that have directly compared the effectiveness of Xiaflex (collagenase) to verapamil injections for the treatment of Peyronie’s disease.

Based on the indirect comparison, it appears that both Xiaflex and verapamil injections have some efficacy in Peyronie’s disease.  It is likely that Xiaflex may be somewhat more effective for some men than Verapamil, in particular for men with an early disease with a minimally calcified palpable plaque.

Both Xiaflex and verapamil appear to work best for men with less calcified Peyronie’s plaques.

Typically, both Xiaflex and verapamil lead to improvement rather than complete resolution of penile curvature.

Cost of Treatment Xiaflex vs Verapamil

Verapamil injections are fairly inexpensive with the total cost of around $500-700 for a course of six injections.  Xiaflex is a fairly expensive medication with a course of the treatment cost of greater than $30,000.  Xiaflex is usually covered by health insurance.

Side Effects: Verapamil vs Xiaflex Injections

Verapamil injections typically cause few if any side effects. Occasionally a small ‘black-and-blue’ spot can appear at the site of injection that goes away in a week or two.

Xiaflex can cause more pronounced swelling around the penis; it can also cause more notable ‘black and blue‘ areas both on the penis and sometimes on the scrotum or the lower abdomen. This is transient and disappears typically within 1-2 weeks.

In rare situations, Xiaflex can lead to ‘penile fracture’, which occurs <1% of the time but requires surgical treatment.

Patients need to stop blood-thinners prior to Xiaflex administration.

Did you know?  Dr. Shteynshlyuger has performed over 1,000 penile surgeries including penile implants, correction of Peyronie’s disease, circumcisions, circumcision revisions, frenuloplasty, and congenital penile curvature.  He performs 150-200 penile surgeries a year.

Where to Get Peyronie’s Treatment in NYC?

At New York Urology Specialists, we offer treatment for men with Peyronie’s disease. 

Call/text today: 1-646-663-4050 or make an appointment online.  

We treat sexual and erection problems and Peyronie’s disease.  We offer comprehensive STD testing for infections.  We treat penile problems in men, including phimosis, balanitis, penile irritation, and penile redness. We perform a no-scalpel vasectomy, vasectomy reversal, cosmetic circumcision, circumcision revision, penile frenuloplasty. We offer confidential appointments.

Our appointment costs are affordable with or without insuranceLow-cost Viagra (sildenafil) and Cialis (tadalafil) are available to our patients.  We offer free insurance verification.

Read Real Stories of Men who Underwent Treatment for Peyronie’s Disease at New York Urology Specialists.

Read RealStories: 32-year-old man with penile curvature and pain treated with verapamil

Read RealStories: 63-year-old man with Peyronies and ED treated with Xiaflex.

Read RealStories: 75-year-old man with penile narrowing and curvature treated with interferon

Cost of Treatment and Insurance

At New York Urology Specialists, we offer affordable treatment for men. Our prices are low for patients without insurance and for those who have high insurance copays, high deductibles, or insurance plans that do not cover treatment costs. 

We accept many health insurance plans.  We would be happy to verify your eligibility and benefits and to provide you with detailed information on your health plan’s coverage.  Financing options and credit options are available to help you pay for medical care.

Why Choose New York Urology Specialists for Treatment of Peyronie’s Disease?

  • All treatment is performed by a board-certified urologist experienced in treating men with symptoms of Peyronie’s disease, including penile curvature, narrowing of the penis, shortening of the penis, pain in the penis, and ED.  
  • We are one of the few practices in the region to offer a full range of options for treatment of Peyronie’s disease, sexual and erection problems in men.
  • We offer diagnostic testing in our office, which avoids hospital costs.
  • Extensive experience: Thousands of men have been treated successfully using medical therapy (Xiaflex, Verapamil injections, Interferon), shockwave therapy for penile pain, penile plication, plaque excision and grafting, and penile implant surgery.
  • Confidential and Understanding Care. We understand that most of our patients desire privacy.  We see patients with a variety of urological problems. Your reason for visiting us is entirely confidential.
  • We offer diagnostic testing in our office, which avoids hospital costs.
  • We are conveniently located within a 30-60 minute commute to men who are seeking ED treatment in Manhattan, Brooklyn, Queens, Staten Island, Westchester, Long Island, Bronx, and New Jersey.

What does Peyronie’s Penile Curvature Look Like?

You can find before and after treatment images in our image gallery.

Scheduling Appointments for Peyronie’s Treatment at New York Urology Specialists


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance.


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Peyronies Disease and ED Are Treatable in Nearly Every Man

Excellence-Urology_Care-banner2At New York Urology Specialists, our urologists are specially trained in the evaluation and treatment of Peyronie’s disease and erectile dysfunction.  We understand the challenges that Peyronie’s disease and ED create for our patients, their relationships, and their self-esteem.  We help you find a treatment for Peyronie’s disease that fits your needs, lifestyle, and your preferences.

Urologists are doctors specializing in the treatment of men with sexual problems including Peyronie’s disease and erectile dysfunction. By virtue of our experience and skill, we are able to offer an effective treatment option for nearly every man who desires an effective treatment for ED.  We offer medical and surgical treatment for Peyronie’s disease and erectile dysfunction.

We Treat Some of the Most Complex Peyronie’s Problems and Men’s Health Problems Including:

Schedule an Appointment with Dr. Shteynshlyuger:

Call/text today: 1-646-663-4050 or make an appointment online

Dr. Alex Shteynshlyuger is a fellowship-trained, board-certified urologist with expertise in the evaluation and treatment of sexual and erection problems in men using modern, effective, and proven treatment methods.  We offer inflatable penile implant, shockwave therapy for ED, and treatment for Peyronie’s disease.

He is highly recommended by top primary care physicians in the New York area. If you or someone you know has been experiencing urological symptoms, make an appointment to take advantage of Dr. Shteynshlyuger’s expert advice. Please feel free to contact us with any questions.


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance. 

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