Xiaflex for Peyronie’s Disease in New York

by Alex Shteynshlyuger MD

If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance.

What is Xiaflex?

Xiaflex is a brand name for collagenase (USA; in Europe the brand name is Xiapex), a naturally occurring enzyme that is involved in tissue repair.  XIAFLEX is the first FDA-approved medication for the treatment of Peyronie’s disease.  It is effective for the treatment of moderate to severe Peyronie’s Disease.

Xiaflex is a naturally occurring enzyme called collagenase. Collagenase breaks down collagen which is a protein that is present in scar tissue.  By breaking scar tissue, Xiaflex treats the cause of Peyronie’s disease directly.

Peyronie's TreatmentWho is a Candidate for Xiaflex/Xiapex Treatment?

FDA approved XIAFLEX for use in men with at least 30-degree penile curvature and a palpable plaque (which is necessary to inject into it).

Read more about Xiaflex treatment for Peyronie’s disease and our patient selection criteria for Xiaflex.  Men should be able to obtain a good erection on their own or with the help of medications such as Viagra or Cialis.  Men should NOT have significant hourglass narrowing of the penis.

Where to Get Peyronie’s Treatment with Xiaflex in NYC?

At New York Urology Specialists, we offer treatment for men with penis problems including Xiaflex administration for Peyronie’s disease

Call/text today: 1-646-663-4050 or make an appointment online.  

We treat sexual and erection problems and Peyronie’s disease.  We offer comprehensive STD testing for infections.  We treat penile problems in men, including phimosis, balanitis, penile irritation, and penile redness. We perform a no-scalpel vasectomy, vasectomy reversal, cosmetic circumcision, circumcision revision, penile frenuloplasty. We offer confidential appointments.

Our appointment costs are affordable with or without insuranceLow-cost Viagra (sildenafil) and Cialis (tadalafil) are available to our patients.  We offer free insurance verification.

Read Real Stories of Men who Underwent Treatment for Peyronie’s Disease at New York Urology Specialists.

Read RealStories: Penile pain in a 51-year old adult male with curvature to the left and up treated with Xiaflex and penile traction.

Read RealStories: 63-year-old man with Peyronies and ED treated with Xiaflex.

Read RealStories: 75-year-old man with penile narrowing and curvature treated with interferon

Read RealStories: 47-year-old man with penile shortening, narrowing and curvature treated with Xiaflex and plaque excision

What is the Procedure for Getting Treated with Xiaflex for Peyronie’s Disease?

Initial evaluation requires 1-3 visits to determine if you’re a good candidate for Xiaflex (have a good chance of benefiting from it).  Usually, you would need a consultation during which we would need to administer an injection to create an artificial erection so that we can properly evaluate the plaque and see if you’re a good candidate for Xiaflex or any other treatments.  Penile Doppler ultrasound is performed.

If you are a candidate for Xiaflex and decide to proceed, we will schedule you for treatment with Xiaflex.  Read more about costs and insurance coverage. Each treatment cycle is approximately 7 days. Injection on day 1; then another injection on day 2-3; then penile remodeling 3-4 days later.

You then are taught to do remodeling by yourself for 7 weeks at home; then a 2nd cycle is given again over a period of 1 week followed by 7 week period of self-remodeling for 4 cycles total. So each cycle is spread by 7 weeks from the next one.  If your curvature becomes <15 degrees then we stop it. The maximum we can do is 4 cycles.  For patients with multiple plaques, if there is a good response, additional treatment can be tried.

Costs of Xiaflex are usually covered by insurance in the USA. There are some insurance companies outside the US that may pay for treatment in the US with Xiaflex.  Financial support programs for patients without insurance and with a high deductible is available.

How Effective is Xiaflex for Treatment of Peyronie’s Disease?

Randomized controlled studies show that Xiaflex is one of the most effective medications for the treatment of Peyronie’s disease in men.  Overall around 60% of men who are ideal candidates for Xiaflex experience some benefit from treatment with Xiaflex. Success rates are lower for patients who are not ideal candidates for Xiaflex.

How is Xiaflex Administered?

Xiaflex is administered by injecting the active medication into the Peyronie’s plaque in the penis.  Usually, the administration is done in combination with penile plaque modeling. Read our detailed explanation of the treatment approach and treatment schedule.

Pain and Anesthetic Expectations:

Xiaflex injection involves a needle injection – usually, there is some discomfort but fairly tolerable for a minute or so that it takes to inject the medication.   There is no general anesthesia (you’re fully awake) but we can give a local anesthetic if you wish. The patient can walk in and walk out of the office.  The pain is what you would expect from an injection.  Patients cannot have sex for 4 weeks after each injection due to the risk of penile fracture.

Xiaflex Success Rates

Success rates vary but studies demonstrate an average 34% improvement in the curvature (or 17-degree decrease from baseline curvature).  60% of men getting Xiaflex experienced improvement compared to 30% with placebo.  Our experience with Xiaflex suggests that the success rate depends on the patient’s disease severity.  

Many patients with Peyronie’s are not ideal candidates for Xiaflex due to plaque calcification.  Patients who are not ideal candidates for Xiaflex typically experience less benefit from Xiaflex.  It is important to understand that not everyone experiences improvement after treatment with Xiaflex. On the other hand, some men experience a dramatic improvement in their curvature.  Xiaflex does not treat hourglass appearance.

Xiaflex Treatment Schedule

Xiaflex is administered in 4 cycles, each cycle is one week long followed by 7 weeks of at-home penile self-remodeling.  Overall it takes close to 6 months to administer the full cycle.  Patients who prefer faster results may consider other treatment options.  Alternative administration protocols are also possible.

At New York Urology Specialists, our Xiaflex treatment schedule includes an initial evaluation to determine if Xiaflex is an appropriate option for the individual man who comes to us with Peyronie’s disease. Some men may be better served with other treatment options for Peyronie’s disease. International patients may undergo initial evaluation in their home country from a local urologist experienced in the treatment of Peyronie’s disease.

What are the Risks of Xiaflex?

Randomized controlled trials revealed that there are a number of risks associated with the injection of Xiaflex in the penile plaque.  These include bruising, hematoma, penile swelling, penile pain as well as a number of other common side effects.  A significant and concerning side effect that has been noted in less than 1% of men who received Xiaflex is a rupture of the corpora albuginea.  This is a major reason that the FDA has approved Xiaflex with the requirement for careful administration by properly trained and experienced urologists.

  • Penile hematoma (bruising, hematoma): 66% – usually minor goes away after 1-2 weeks
  • Severe penile hematoma: 6% goes away after 1-2 weeks
  • Penile Swelling: 55%  goes away after 1-2 weeks
  • Penile Pain: 45%
  • Painful erection: 3%
  • Popping sounds or cracking sounds“: 13%

Corporal rupture: 0.5% (occurs typically within the first 2 weeks after injection; for this reason, no sex is allowed for 4 weeks after each injection).  

Peyronie's treatmentWho is a Candidate for Xiaflex?

Not every patient with Peyronie’s disease is a candidate for Xiaflex.  Currently, men with Peyronie’s with greater than 30-degree angle are candidates.  Men should be able to obtain good erections to qualify.

The plaque cannot be close to the urethra; however, studies show that some men with ventral penile curvature can be safely treated. The indications for using Xiaflex is curvature greater than 30 degrees, preferably with minimal calcification.  Health insurances only cover the cost of treatment for lateral and dorsal penile curvature.

Because the medication works to break up proteins it may not work well (or at all) in heavily calcified plaques (these were excluded from studies). The plaque also needs to be palpable so that we know we are injecting in the right space. There are some additional criteria. Read about our qualifications for Xiaflex treatment.

Costs and Insurance Coverage for Xiaflex (Peyronie’s Disease)

The cost of medication is significant. The good news for men with Peyronie’s disease is that most insurances provide coverage for Xiaflex, including Medicare, UnitedHealthcare, Aetna, Blue Cross plans, and many others.  We work through the Xiaflex Experience program to get your insurance to cover the costs of treatment.  Insurance coverage may also be available for some of our international patients. Read more about costs and insurance coverage for Xiaflex.

Patients with no insurance or high deductible may be well served by other cost-effective treatment options for Peyronie’s disease.

Certified Prescriber of Xiaflex for Peyronie’s Disease in NYC

New York Urology Specialists is One of the First Practices to Use Xiaflex for Peyronie’s disease.

New York Urology Specialists is one of the first and few specialized urology practices in the New York Metropolitan area to become REMS-certified for prescribing Xiaflex (Collagenase) to men with moderate-to-severe Peyronie’s Disease.

Peyronie's & XiaflexDr. Alex Shteynshlyuger is experienced in the treatment of Peyronie’s disease.  New York Urology Specialists achieved FDA-mandated REMS certification in December of 2013, one of the first practices in New York City and the tri-state area to achieve this certification. REMS Healthcare Provider Enrollment ID for New York Urology Specialists is 3000040.

Xiaflex is the first FDA approved treatment for Peyronie’s disease has gained FDA approval in December of 2013 based on efficacy data from randomized controlled trials.

Experienced urologists at New  York Urology Specialists have treated hundreds of patients with Peyronie’s disease.  We offer minimally invasive, medical as well as surgical treatment options for Peyronie’s disease and erectile dysfunction.

Did you know?  Dr. Shteynshlyuger has performed over 1,000 penile surgeries including penile implants, correction of Peyronie’s disease, circumcisions, circumcision revisions, frenuloplasty, and congenital penile curvature.  He performs 150-200 penile surgeries a year.

Cost of Treatment and Insurance

At New York Urology Specialists, we offer affordable treatment for men. Our prices are low for patients without insurance and for those who have high insurance copays, high deductibles, or insurance plans that do not cover treatment costs. 

We accept many health insurance plans.  We would be happy to verify your eligibility and benefits and to provide you with detailed information on your health plan’s coverage.  Financing options and credit options are available to help you pay for medical care.

Why Choose New York Urology Specialists for Treatment of Peyronie’s Disease?

  • All treatment is performed by a board-certified urologist experienced in treating men with symptoms of Peyronie’s disease, including penile curvature, narrowing of the penis, shortening of the penis, pain in the penis, and ED.  
  • We are one of the few practices in the region to offer a full range of options for treatment of Peyronie’s disease, sexual and erection problems in men.
  • We offer diagnostic testing in our office, which avoids hospital costs.
  • Extensive experience: Thousands of men have been treated successfully using medical therapy (Xiaflex, Verapamil injections, Interferon), shockwave therapy for penile pain, penile plication, plaque excision and grafting, and penile implant surgery.
  • Confidential and Understanding Care. We understand that most of our patients desire privacy.  We see patients with a variety of urological problems. Your reason for visiting us is entirely confidential.
  • We offer diagnostic testing in our office, which avoids hospital costs.
  • We are conveniently located within a 30-60 minute commute to men who are seeking ED treatment in Manhattan, Brooklyn, Queens, Staten Island, Westchester, Long Island, Bronx, and New Jersey.

What does Peyronie’s Penile Curvature Look Like?

You can find before and after treatment images in our image gallery.

Scheduling Appointments for Peyronie’s Treatment at New York Urology Specialists

If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance.

Dr. Alex Shteynshlyuger is a board-certified urologist and specialist in the treatment of sexual problems in men including Peyronie’s disease and erectile dysfunction.  He is one of the few urologists who offers a full range of treatment options for Peyronie’s disease and ED.  He has successfully treated thousands of men with sexual problems.

Patients Reviews

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Total Ratings


Total Reviews



Ease of Appointment: Bedside Manner:
Promptness: Spends Time with Me:
Courteous Staff: Follows Up After Visit:
Accurate Diagnosis:

The Best of the Best
by on Dec 14, 2023

The Best of the Best Webster dictionary defines perfect as being entirely without fault or defect. This is Dr. Alex personified. This doctor is truly exceptional! From the moment I entered the doors to the office, I felt welcomed, cared for, and completely at ease. Dr. Alex Shteynshlyugerhas gone above and beyond to be sure that my complete health and wellness have been made first priority.He is extremely knowledgable and personable. I never was made to wait. And if ever I needed to contact him or his staff, they were super speedy in responding by my inquiries. The office is inviting and his beautiful staff members are friendly and helpful in every way. I feel very comfortable in his care and would recommend him to anyone who needs a doctor. Larry Keshinover - December 11, 2023

best urology doctor
by on Feb 14, 2021

Dr Alex Shteynshlyuger is the best urology doctor there is. He is attentive, analytical, knowledgeable and skillful. Very confidential with a masterfully professional staff. I would not hesitate in recommending Dr Shteynshlyuger to the world because I am a satisfied patient of his.

solved my problem with ED
by on Jan 29, 2021

Dr. Shteynshlyuger helped to solve my problem with ED

Very Pleased
by on Jan 21, 2021

Very Pleased, I couldn’t have asked for more from Dr. S as well as everyone in the office, The procedure and after was a dream with Dr. S. If you are on the fence, I can tell you, that you will love your experience with Dr. S

by on Jan 11, 2021


recommend Dr. Shteynshlyuger
by on Jan 04, 2021

Yes I would recommend Dr. Shteynshlyuger . Effective physician at all levels.

No pain at all
by on Nov 25, 2020

This was a very fast and easy process. No pain at all and the job was very well done. He stays on top of your progress and helps to heal faster. I will definitely recommend Dr Alex at all times!!!

I would highly recommend it to anyone
by on Oct 11, 2020

I saw the reviews about this place and was very hesitant to go but something was telling me to go with them and I don't regret it at all, the doctor did a great job and helped me understand the process plus the staff was amazing I would highly recommend it to anyone! quick story after the procedure I was in soo much pain and called the office on a SUNDAY, the doctor gave me a call back within 15 minutes and prescribed a stronger medication, to me that meant a lot for the doctor to take time from his day on a Sunday to help me.

successful procedure
by on Aug 20, 2020

To Dr. Shteynshlyuger and your assistants and aids, thank you guys for a successful procedure. I'd refer you to others for your compassionate, knowledgeable, attentive service and indepth follow up care.

very friendly staff
by on Apr 12, 2020

excellent doctor and all very friendly staff

Doctor Shteynshlyuger provided me with the care I needed
by on Mar 11, 2020

The staff is very professional. Doctor Shteynshlyuger provided me with the care I needed. The wait, visits, and instructions were brief. I followed his instructions and my issue was resolved. As a patient exercise patience. Follow the instructions and be honest about your condition and what you hope to accomplish be visiting. Thanks again Doctor.

Patient review
by on Jan 24, 2020

Thank you doc !!!
by on Aug 14, 2019

Great doctor, good bedside manner and always felt comfortable talking to him and the staff. Great location and affordable prices. Thank you doc !!!

What went well

Appointment scheduling Office environment Staff friendliness Appointment wasn't rushed Listened & answered questions Explained conditions well Trusted the provider's decisions

positive experience
by on Aug 09, 2019

Dr. Shteynshlyuger is professional, knowledgeable, and experienced. I had a positive experience with him.

Peronis Disease
by on Aug 04, 2019

Dr Alex was both knowledgeable and concise with his diagnosis and advice which was well received. Dr was her knowledgeable in the subject and provided good advice.

by on Jul 18, 2019

Therefore I would like to recommend you to anyone who need your services.

Urology Visit
by on Jul 18, 2019

Staff were all very welcoming. Dr. Alex Shteynshlyuger was very knowledgeable and attentive during my time spent with him.

by on Jul 09, 2019

Went in for a procedure with Dr. Alex and he was very calm and thorough about the the operation and the recovery. From the front desk to his assistants, everyone was very courteous, professional and polite. I highly recommend NY Urologist Specialist. They are outstanding!!!

Care at NY Urology Specialists
by on Jul 06, 2019

I am a 54 year-old male who is extremely happy with my care at New York Urology Specialists. I came to see Dr. Alex out of near desperation after consulting with three other urologists. Literally over one night, I began experiencing severe penile pain and burning. None of the other urologists were able to help diagnose what my problem was and seemingly didn't take my problem very seriously. In fact, one of them specifically told me at it had nothing to do with my prostate. After 6 weeks of suffering, I saw Dr. Alex. He examined me and gave me some tests and lab work. He very quickly ascertained that my problem was due to an enlarged prostate. He proscribed medicine to deal with my pain in the short-term and keep my prostate size in check over the long-term. My problem quickly disappeared. Today, 5 years later, I feel great. Dr, Alex listens to you as a patient, takes your opinion and health concerns seriously and knows his field inside-and-out so that you can get proper treatment for your problem. I can't thank him enough for diagnosing and solving my malady - you sometimes can't appreciate a problem until you have it. Getting rid of it and getting back to normal is so important - I am so glad that I saw Dr. Alex for my problem.

Professional staff as well as the Doctor
by on Jun 18, 2019

Professional staff as well as the Doctor

First class Surgeon & staff
by on Sep 24, 2018

From the very appointment to the last follow-up visit, I felt I was at the right place and with the right people around me. Dr. Alex Stheynshlyuger and his staff made it easy and confortable. I would recommend them to every man.

Friendly , courteous, effiecient and professional
by on Sep 15, 2018

Wyts Wyts recommends New York Urology Specialists via Facebook. September 15, 2018 · Friendly , courteous, effiecient and professional staff members. This office i highly recommend for any and all Urology matters. Dr Alex Shteynshlyuger is very professional and knowledgable easy to communicate with. Thanks Dr Alex

Satisfied Patient
by on Sep 15, 2018

I am very please and satisfied with everything that has been offorded to me by New York Urology Specialist Office.....Dr Alex

Surgical Procedure
by on Sep 01, 2018

Dr Alex and his staff are through professionals in every sense of the word. From initial diagnosis to a period of evaluating and ruling out options, we decided upon a surgical solution, which appears for the most part to have corrected the issue. Thanks to Ana, and the staff, especially Dr. Alex for treating me so well. Best regards, Lee

by on Aug 16, 2018

Outstanding service

urology services
by on Apr 11, 2018

I am very satisfied with the treatment I received at new york urology specialist and would recommend them to other patients.they are the very best.

My wife was elated
by on Jan 15, 2018

Well I put it to use last night and man, good job. My wife was elated. u made it much better somehow, so thank u for fixing my penis

by on Nov 19, 2017

I am writing to thank dr. Alex. He is thorough, professional, knowledgeable, helpful and friendly. I have seen him for ED and prostate issues, and he has explained all my options clearly, and found solutions that have been a great help. thank you! I highly recommend both Dr. Alex and his staff, which I find to be helpful, friendly, knowledgeable and very professional. They are a pleasure to deal with and all have been a great help.

Dr visit
by on Sep 14, 2017

I am very much thankful for meeting Dr Alex .I had a very serious medical problem I visited many doctors but none could not help me it was very difficult for me until I visited Dr Alex after a couple visits my medical problem is no more I feel very great also I felt almost 20 years younger Dr Alex is second to none fantastic doctor. Thanks again Dr Alex from my family.

Excellent doctor
by on Jul 03, 2014

I am feeling better now after visiting clinic New York urology specialists. Excellent staff and appointment on time.

Thank you for excellent care
by on Jan 07, 2013

Dear Dr. Alex: We want to thank you for the excellent care you provided for George during his emergency operation and the follow up treatment. Your quiet, confident manner was reassuring to us during a very scary time for us. We will never forget you. George Sally R. Date: 2013

We love you!
by on Feb 16, 2012

Dr. Alex Shteynshlyuger and Staff – Thank you so much for taking care of my husband Bob. Dr. Alex: I thank God everyday for you. You were an answer to prayer.

Peyronies Disease and ED Are Treatable in Nearly Every Man

Excellence-Urology_Care-banner2At New York Urology Specialists, our urologists are specially trained in the evaluation and treatment of Peyronie’s disease and erectile dysfunction.  We understand the challenges that Peyronie’s disease and ED create for our patients, their relationships, and their self-esteem.  We help you find a treatment for Peyronie’s disease that fits your needs, lifestyle, and your preferences.

Urologists are doctors specializing in the treatment of men with sexual problems including Peyronie’s disease and erectile dysfunction. By virtue of our experience and skill, we are able to offer an effective treatment option for nearly every man who desires an effective treatment for ED.  We offer medical and surgical treatment for Peyronie’s disease and erectile dysfunction.

We Treat Some of the Most Complex Peyronie’s Problems and Men’s Health Problems Including:

Schedule an Appointment with Dr. Shteynshlyuger:

Call/text today: 1-646-663-4050 or make an appointment online

Dr. Alex Shteynshlyuger is a fellowship-trained, board-certified urologist with expertise in the evaluation and treatment of sexual and erection problems in men using modern, effective, and proven treatment methods.  We offer inflatable penile implant, shockwave therapy for ED, and treatment for Peyronie’s disease.

He is highly recommended by top primary care physicians in the New York area. If you or someone you know has been experiencing urological symptoms, make an appointment to take advantage of Dr. Shteynshlyuger’s expert advice. Please feel free to contact us with any questions.

If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance. 


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