Penile Intralesional Plaque Injection Therapy for Peyronie’s Disease

by Alex Shteynshlyuger MD


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance.

Dr. Alex Shteynshlyuger is a board-certified urologist in NYC who specializes in treating men with Peyronie’s disease.


Penile Injections for Peyronie’s Disease

Penile traction therapyPenile injection therapy refers to the direct injection of medications into the scar tissue or “penile plaque“.

It is important to understand that only patients who have a palpable nodule or lump in the penis can be treated with intralesional injections.  The urologist must be able to feel the lump “Peyronie’s plaque” in order to inject medications in it.

No Palpable Lump = No Injections

Patients who have symptoms of Peyronie’s disease such as bent penis, pain, and narrowing but do not have a lump that can be felt during a physical exam are not candidates for penile injections.  If the symptoms are recent, some patients subsequently will develop a palpable Peyronie’s plaque and may become candidates for injections.  Patients without a palpable Peyronie’s plaque can be treated with penile traction therapy, penile plication, and penile implant. Men with a recent onset of Peyronie’s disease symptoms who do not have a palpable scar may develop Peyronie’s plaque with time and become candidates for penile plaque injections.

Penile Injections for Peyronie’s Disease Have a Good Safety Record.

Injection of medication in the penile plaque is typically less invasive than surgery and has few side effects.  It is the preferred first treatment option for men with Peyronie’s disease with a palpable ‘cord’ or plaque’.  To be good candidates for plaque injections, men should have good erections with or without medications such as Cialis and Viagra. Patients with severe ‘hourglass’ appearance are better candidates for other treatment options.  Penile injection therapy for Peyronie’s disease does not have a dramatic effect on the hourglass appearance.

What Medications are Used for Injections directly into Penile Plaque?

Medications that are injected into the penile plaque include verapamil, Xiaflex, and interferon.

How Effective are Penile Injections?

There are three different medications available to be used for intralesional injections for men with Peyronie’s disease.  While no study has compared them to each other, it appears that they have similar efficacy.  These medications tend to work for about 30-40% of men.  If one medication does not work, it is possible to try a different medication.  Typically, at New York Urology Specialists, we advise that men use penile traction therapy in combination with penile injection therapy.

It is rare for medications to produce a perfectly straight penis.  Typically injectable medications lead to improvement but not complete resolution of curvature.  The success of treatment depends on plaque size, the severity of penile curvature, and a number of other factors.

If injection therapy does not help, surgical treatment with penile plication, plaque incision/excision, and grafting, or penile implant are effective treatment options for most men.

How Painful are the Injections?

Penile injections can cause mild to moderate pain. The injection typically takes only 1-2 minutes to perform. Some men prefer an injection of a local anesthetic; others choose to just bear the discomfort for the duration of injection.

Cost and Insurance Coverage of Penile Injections

Treatment of Peyronie’s disease with penile injections is typically covered by health insurance plans. The exact cost depends on the medication used. Verapamil and interferon are less expensive; Xiaflex is more expensive.  Medication prices change frequently.  Please contact us for current pricing.

Read Real Stories of Men who Underwent Treatment for Peyronie’s Disease at New York Urology Specialists.

Read RealStories: 67-year-old man with dorsal curvature and ED after the use of Trimix injections.

Read RealStories: 53-year-old man with 45-degree dorsal curvature and pain

Read RealStories: Penile pain in a 51-year old adult male with curvature to the left and up treated with Xiaflex and penile traction.

Read RealStories: 32-year-old man with penile curvature and pain treated with verapamil

Read RealStories: 63-year-old man with Peyronies and ED treated with Xiaflex.

Read RealStories: 75-year-old man with penile narrowing and curvature treated with interferon

Did you know?  Dr. Shteynshlyuger has performed over 1,000 penile surgeries including penile implants, correction of Peyronie’s disease, circumcisions, circumcision revisions, frenuloplasty, and congenital penile curvature.  He performs 150-200 penile surgeries a year.

Where to Get Peyronie’s Treatment in NYC?

At New York Urology Specialists, we offer treatment for men with Peyronie’s disease. 

Call/text today: 1-646-663-4050 or make an appointment online.  

We treat sexual and erection problems and Peyronie’s disease.  We offer comprehensive STD testing for infections.  We treat penile problems in men, including phimosis, balanitis, penile irritation, and penile redness. We perform a no-scalpel vasectomy, vasectomy reversal, cosmetic circumcision, circumcision revision, penile frenuloplasty. We offer confidential appointments.

Our appointment costs are affordable with or without insuranceLow-cost Viagra (sildenafil) and Cialis (tadalafil) are available to our patients.  We offer free insurance verification.

Cost of Treatment and Insurance

At New York Urology Specialists, we offer affordable treatment for men. Our prices are low for patients without insurance and for those who have high insurance copays, high deductibles, or insurance plans that do not cover treatment costs. 

We accept many health insurance plans.  We would be happy to verify your eligibility and benefits and to provide you with detailed information on your health plan’s coverage.  Financing options and credit options are available to help you pay for medical care.

Why Choose New York Urology Specialists for Treatment of Peyronie’s Disease?

  • All treatment is performed by a board-certified urologist experienced in treating men with symptoms of Peyronie’s disease, including penile curvature, narrowing of the penis, shortening of the penis, pain in the penis, and ED.  
  • We are one of the few practices in the region to offer a full range of options for treatment of Peyronie’s disease, sexual and erection problems in men.
  • We offer diagnostic testing in our office, which avoids hospital costs.
  • Extensive experience: Thousands of men have been treated successfully using medical therapy (Xiaflex, Verapamil injections, Interferon), shockwave therapy for penile pain, penile plication, plaque excision and grafting, and penile implant surgery.
  • Confidential and Understanding Care. We understand that most of our patients desire privacy.  We see patients with a variety of urological problems. Your reason for visiting us is entirely confidential.
  • We offer diagnostic testing in our office, which avoids hospital costs.
  • We are conveniently located within a 30-60 minute commute to men who are seeking ED treatment in Manhattan, Brooklyn, Queens, Staten Island, Westchester, Long Island, Bronx, and New Jersey.

What does Peyronie’s Penile Curvature Look Like?

You can find before and after treatment images in our image gallery.

Scheduling Appointments for Peyronie’s Treatment at New York Urology Specialists


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance.


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Peyronies Disease and ED Are Treatable in Nearly Every Man

Excellence-Urology_Care-banner2At New York Urology Specialists, our urologists are specially trained in the evaluation and treatment of Peyronie’s disease and erectile dysfunction.  We understand the challenges that Peyronie’s disease and ED create for our patients, their relationships, and their self-esteem.  We help you find a treatment for Peyronie’s disease that fits your needs, lifestyle, and your preferences.

Urologists are doctors specializing in the treatment of men with sexual problems including Peyronie’s disease and erectile dysfunction. By virtue of our experience and skill, we are able to offer an effective treatment option for nearly every man who desires an effective treatment for ED.  We offer medical and surgical treatment for Peyronie’s disease and erectile dysfunction.

We Treat Some of the Most Complex Peyronie’s Problems and Men’s Health Problems Including:

Schedule an Appointment with Dr. Shteynshlyuger:

Call/text today: 1-646-663-4050 or make an appointment online

Dr. Alex Shteynshlyuger is a fellowship-trained, board-certified urologist with expertise in the evaluation and treatment of sexual and erection problems in men using modern, effective, and proven treatment methods.  We offer inflatable penile implant, shockwave therapy for ED, and treatment for Peyronie’s disease.

He is highly recommended by top primary care physicians in the New York area. If you or someone you know has been experiencing urological symptoms, make an appointment to take advantage of Dr. Shteynshlyuger’s expert advice. Please feel free to contact us with any questions.


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance. 

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