Penile Intralesional Plaque Injection Therapy for Peyronie’s Disease

by Alex Shteynshlyuger MD


If you have any questions, to schedule a consultation or if you need a second opinion, please contact us or call 1-(646) 663-4050.

Dr. Alex Shteynshlyuger is a board-certified urologist in NYC who specializes in treating men with Peyronie’s disease.


Penile Injections for Peyronie’s Disease

Penile traction therapyPenile injection therapy refers to the direct injection of medications into the scar tissue or “penile plaque“.

It is important to understand that only patients who have a palpable nodule or lump in the penis can be treated with intralesional injections.  Urologist must be able to feel the lump “Peyronie’s plaque” in order to inject medications in it.

No Palpable Lump = No Injections

Patients who have symptoms of Peyronie’s disease such as bent penis, pain, and narrowing but do not have a lump that can be felt during a physical exam are not candidates for penile injections.  If the symptoms are recent, some patients subsequently will develop a palpable Peyronie’s plaque and may become candidates for injections.

Penile Injections for Peyronie’s Disease Have a Good Safety Record.

Injection of medication in the penile plaque is typically less invasive and has few side effects.  It is the preferred first treatment option for men with Peyronie’s disease with a palpable ‘cord’ or plaque’.  To be good candidates for plaque injections, men should have good erections with or without medications such as Cialis and Viagra. Patients with severe ‘hourglass’ appearance are better candidates for other treatment options.

What Medications are Used for Injections directly into Penile Plaque?

Medications that are injected into the penile plaque include verapamil, Xiaflex, and interferon.

How Effective are Penile Injections?

There are three different medications available to be used for intra-lesional injections for men with Peyronie’s disease.  While no study has compared them to each other, it appears that they have similar efficacy.  These medications tend to work for about 30% of men.  If one medication does not work, it is possible to try a different medication.  Typically, at New York Urology Specialists, we advise that men use penile traction therapy in combination with penile injection therapy.

It is rare for medications to produce a perfectly straight penis.  Typically injectable medications lead to improvement but not complete resolution of curvature.  The success of treatment depends on plaque size, the severity of penile curvature and a number of other factors.

If injection therapy does not help, surgical treatment with penile plication, plaque incision/excision and grafting or penile implant are effective treatment options for most men.


If you have any questions, to schedule a consultation or if you need a second opinion, please contact us or call 1-(646) 663-4050.

We offer affordable, highest-quality urology care.


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