Treatment for Erectile Dysfunction with MUSE (intraurethral alprostadil)

by Dr. Alex Shteynshlyuger

If you have any questions, to schedule a consultation or if you need a second opinion, please contact us or call 1-(646) 663-5211.

What is MUSE?

Intraurethral alprostadil (MUSE)

MUSE for ED Treatment

MUSE is a brand name for a medication used for the treatment of erectile dysfunction in men.  MUSE comes as a small pill or pellet that is inserted into the tip of the penis (urethra) just prior to sexual intercourse.  The actual active component of this medication is alprostadil.

MUSE is an effective treatment option for erectile dysfunction and is used by many men.  The key to the use of this medication is to choose the correct dose of MUSE that provides an effective erection.

MUSE can also be used as an adjunct with other treatment options for erectile dysfunction to produce a more satisfactory erection.

What are the Common Side Effects of MUSE?

Some men may experience side effects from MUSE. The most common side effect is burning sensation in the penis after administration of this medication intraurethrally.  This side effect is not dangerous and reversible, usually goes away after a few hours.  Priapism or an erection that lasts more than 4 hours is another relatively rare side effect.

Does MUSE Work for Everyone?

Very few treatments work for everyone.  A thorough evaluation is advisable prior to initiation of treatment for erectile dysfunction.  While MUSE works for many men, it does not work for everyone.

Other treatment options are available for erectile dysfunction when MUSE is not effective or causes side effects

Yet, for men for whom PDE-5 inhibitors (Viagra, Cialis, and Levitra) do not work well, combination therapy with MUSE or non-oral therapies such as MUSE are of importance. If you have failed to respond to Viagra or Viagra is not fully effective then MUSE may be the right option for you.  Other treatment options include a vacuum pump, penile injections, and penile prosthesis.

MUSE cannot be used more than 3 times a week and each use must be spaced out by 24 hours. MUSE is not advisable if you are at risk for priapism.

How to Use MUSE?

MUSE needs to be stored in the refrigerator.  

The MUSE suppository is the size of a grain of rice. It is delivered into the urethra with a plastic applicator after voiding. It is important to urinate before using MUSE as you do not want to urinate after putting MUSE inside your urethra otherwise you will pee it out.

Lubrication with KY jelly or water may reduce discomfort. A slight stinging sensation may be felt, which should quickly abate when the penis is rolled between the fingers. Gentle massage and standing and walking around make MUSE more effective.

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What You Need to Know:

If you have any questions, to schedule a consultation or if you need a second opinion, please contact us or call 1-(646) 663-5211.

We offer affordable, highest-quality urology care with or without insurance.   Find out our office hours or directions to our office. We offer weekday, weekend and evening office hours.  New York Urology Specialists is a top practice for treatment of erection problems in men in Manhattan, New Jersey, Brooklyn, Queens, Bronx, Long Island and Westchester.  We also treat international patients from other countries visiting the US.


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