Oral Medications Used for Treatment of Peyronie’s Disease

by Alex Shteynshlyuger MD


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What Pills are Effective for Treatment of Peyronie’s Disease

Oral Treatment Peyronie'sIn general, currently available oral medications that have been shown to help men with Peyronie’s disease have limited effectiveness.

Typically improvement seen with oral medications alone is not sufficient to make a significant improvement in most symptoms of Peyronie’s disease.

Oral medications are best used in combination with other treatment options, in particular, injection therapy.

In my view, the reason to use oral therapies is two-fold:

  1. It may help some men with pain symptoms caused by Peyronie’s disease.  These medications include Cialis and Potaba.
  2. Prevent the worsening of penile curvature and prevent disease progression: CoQ10 has been suggested to have a beneficial effect. Since it’s a safe supplement, and good for the heart as well, – I recommend it generously.  

What Oral Treatments Have No Benefit?

Just as important as knowing what works, it is important to know what does not work.

Colchicine, vitamin E, and tamoxifen do not help with Peyronie’s disease and should not be used for that purpose.

CoQ10 (Co-enzyme Q10) for Peyronie’s

CoQ10CoQ10 is a non-prescription vitamin/supplement that has been found to have a beneficial effect on Peyronie’s disease.

While the benefit is not tremendous, CoQ10 is very safe; it is inexpensive, and as an added benefit is good for your heart.

It appears that CoQ10 is most likely beneficial to men with new Peyronie’s disease without a hard calcified Peyronie’s plaque. Studies suggest that at the very least CoQ10 helps prevent disease progression and worsening of the curvature and other symptoms of Peyronie’s disease

CoQ10 is a very safe supplement. As a matter of fact, it is also beneficial for the heart and is often recommended supplement by cardiologists.

The typical recommended dose of CoQ10 is 300-600 mg once a day.

http://www.ncbi.nlm.nih.gov/pubmed/19863517

Potaba (Aminobenzoate Potassium)

Potaba appears to benefit men with penile pain caused by Peyronie’s disease.  Potaba requires a fairly challenging regimen of multiple doses a day.  Other options for the treatment of penile pain include tadalafil daily, shockwave therapy, verapamil injections, and interferon injections.  We do not prescribe Potaba often.

Pentoxifylline for Peyronie’s disease: What’s the Evidence?


Peyronie's in MenPentoxifylline
has been found to have a beneficial effect on men with Peyronie’s disease in one randomized control study.  However, in 2015, the paper was retracted by the authors – apparently statistical analysis was incorrectly done

At this point there is no data to support that pentoxifylline has a significant beneficial effect on the course of Peyronie’s disease.  Mechanism of action of pentoxifylline suggests that it may have a beneficial effect for Peyronie’s.

At this point, I do not advise pentoxifylline for the treatment of men with Peyronie’s disease.  Oral therapy for Peyronie’s disease, in general, is not very effective.

http://www.ncbi.nlm.nih.gov/pubmed/19863517

Learn more about currently recommended treatment options for Peyronie’s disease.

Did you know?  Dr. Shteynshlyuger has performed over 1,000 penile surgeries including penile implants, correction of Peyronie’s disease, circumcisions, circumcision revisions, frenuloplasty, and congenital penile curvature.  He performs 150-200 penile surgeries a year.

Where to Get Peyronie’s Treatment in NYC?

At New York Urology Specialists, we offer treatment for men with Peyronie’s disease. 

Call/text today: 1-646-663-4050 or make an appointment online.  

We treat sexual and erection problems and Peyronie’s disease.  We offer comprehensive STD testing for infections.  We treat penile problems in men, including phimosis, balanitis, penile irritation, and penile redness. We perform a no-scalpel vasectomy, vasectomy reversal, cosmetic circumcision, circumcision revision, penile frenuloplasty. We offer confidential appointments.

Our appointment costs are affordable with or without insuranceLow-cost Viagra (sildenafil) and Cialis (tadalafil) are available to our patients.  We offer free insurance verification.

Read Real Stories of Men who Underwent Treatment for Peyronie’s Disease at New York Urology Specialists.

Read RealStories: Peyronie’s disease in a 46-year-old man with ventral curvature treated with penile plication

Read RealStories: 67-year-old man with dorsal curvature and ED after the use of Trimix injections.

Read RealStories: 53-year-old man with 45-degree dorsal curvature and pain

Read RealStories: Penile pain in a 51-year old adult male with curvature to the left and up treated with Xiaflex and penile traction.

Read RealStories: 32-year-old man with penile curvature and pain treated with verapamil

Read RealStories: 58-year-old man with penile shortening and narrowing after prostate cancer treatment treated with a penile implant and grafting.

Read RealStories: 63-year-old man with Peyronies and ED treated with Xiaflex.

Read RealStories: 75-year-old man with penile narrowing and curvature treated with interferon

Read RealStories: 47-year-old man with penile shortening, narrowing and curvature treated with Xiaflex and plaque excision

Cost of Treatment and Insurance

At New York Urology Specialists, we offer affordable treatment for men. Our prices are low for patients without insurance and for those who have high insurance copays, high deductibles, or insurance plans that do not cover treatment costs. 

We accept many health insurance plans.  We would be happy to verify your eligibility and benefits and to provide you with detailed information on your health plan’s coverage.  Financing options and credit options are available to help you pay for medical care.

Why Choose New York Urology Specialists for Treatment of Peyronie’s Disease?

  • All treatment is performed by a board-certified urologist experienced in treating men with symptoms of Peyronie’s disease, including penile curvature, narrowing of the penis, shortening of the penis, pain in the penis, and ED.  
  • We are one of the few practices in the region to offer a full range of options for treatment of Peyronie’s disease, sexual and erection problems in men.
  • We offer diagnostic testing in our office, which avoids hospital costs.
  • Extensive experience: Thousands of men have been treated successfully using medical therapy (Xiaflex, Verapamil injections, Interferon), shockwave therapy for penile pain, penile plication, plaque excision and grafting, and penile implant surgery.
  • Confidential and Understanding Care. We understand that most of our patients desire privacy.  We see patients with a variety of urological problems. Your reason for visiting us is entirely confidential.
  • We offer diagnostic testing in our office, which avoids hospital costs.
  • We are conveniently located within a 30-60 minute commute to men who are seeking ED treatment in Manhattan, Brooklyn, Queens, Staten Island, Westchester, Long Island, Bronx, and New Jersey.

What does Peyronie’s Penile Curvature Look Like?

You can find before and after treatment images in our image gallery.

Scheduling Appointments for Peyronie’s Treatment at New York Urology Specialists


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance.

Dr. Alex Shteynshlyuger is a board-certified urologist and specialist in the treatment of sexual problems in men including Peyronie’s disease and erectile dysfunction.  He is one of the few urologists who offers a full range of treatment options for Peyronie’s disease and ED.  He has successfully treated thousands of men with sexual problems.

When it comes to the treatment of Peyronie’s disease – New York Urology Specialists are a step ahead.  Better Science Means Better Care.   Dr. Alex Shteynshlyuger is a specialist in treating erection and penis problems using the latest scientific and medical breakthroughs.

Find out our office hours or directions to our office


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Peyronies Disease and ED Are Treatable in Nearly Every Man

Excellence-Urology_Care-banner2At New York Urology Specialists, our urologists are specially trained in the evaluation and treatment of Peyronie’s disease and erectile dysfunction.  We understand the challenges that Peyronie’s disease and ED create for our patients, their relationships, and their self-esteem.  We help you find a treatment for Peyronie’s disease that fits your needs, lifestyle, and your preferences.

Urologists are doctors specializing in the treatment of men with sexual problems including Peyronie’s disease and erectile dysfunction. By virtue of our experience and skill, we are able to offer an effective treatment option for nearly every man who desires an effective treatment for ED.  We offer medical and surgical treatment for Peyronie’s disease and erectile dysfunction.

We Treat Some of the Most Complex Peyronie’s Problems and Men’s Health Problems Including:

Schedule an Appointment with Dr. Shteynshlyuger:

Call/text today: 1-646-663-4050 or make an appointment online

Dr. Alex Shteynshlyuger is a fellowship-trained, board-certified urologist with expertise in the evaluation and treatment of sexual and erection problems in men using modern, effective, and proven treatment methods.  We offer inflatable penile implant, shockwave therapy for ED, and treatment for Peyronie’s disease.

He is highly recommended by top primary care physicians in the New York area. If you or someone you know has been experiencing urological symptoms, make an appointment to take advantage of Dr. Shteynshlyuger’s expert advice. Please feel free to contact us with any questions.


If you have any questions, to schedule a consultation, please contact us or call/text: 1-646-663-4050.

We have excellent reviews from patients and their partners.  Information for out-of-state and international patients.  

We offer affordable prices with or without insurance. 

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